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185.
Which of the following statements characterizes chronic obstructive pulmonary disease (COPD)?
1) usually there is a gradual disease progression over years despite treatment;
2) many patients have a history of allergies and asthma in childhood or in their family history;
3) symptoms worsen at night or in the morning;
4) during asymptomatic periods lung function is abnormal;
5) during asymptomatic periods lung function is normal;
6) chronic cough and sputum expectoration precede the onset of dyspnoea.
The correct answer is: